Senior Mechanical Design Engineer

Redwood City, California, United States Full-time

We are looking for a Senior Mechanical Design Engineer to join our team and help create the world’s first fully automated, cloud-enabled, molecular biology lab.

This position will own numerous projects, help build the tools to enable industrial-scale molecular biology research, and bring automation to genome engineering.

Location: Redwood City, CA (applicants local to the Bay Area only).




  • Technical leadership in mechanical design and active fluidics development supporting a team of mechanical and instrument engineers in building liquid transfer and control systems ranging from microliters to litres
  • Own the architecture of core scientific instrument subsystems and contribute to factory scale process piping design in an industrial and laboratory automation setting
  • Characterize and optimize the performance of highly complex fluid control instrumentation using best engineering practices and data driven decision making



  • 5+ years of experience in mechanical or systems design
  • 2+ year of experience in industrial automation, instrument design, or systems engineering
  • You have designed, built, tested and deployed complex automated instruments
  • You have had a very high level of ownership of the projects you worked on
  • You have designed and built in an industrial context where reliability matters
  • You have an extensive portfolio of badass projects to show us
  • You have a knack for cross-disciplinary problem-solving
  • You know when to outsource and when you need to build it yourself
  • You love to work in a fast-paced, innovative and collaborative environment
  • You are skilled at methodical self-management and project-management
  • You have a great sense of humor :-)
  • BS/MS in Mechanical Engineering and related work experience



  • SolidWorks, SolidWorks, SolidWorks
  • Demonstrated mastery of pneumatics and fluid control
  • Experience with applied material science (chemical compatibility)
  • Ability to characterize and optimize complex system with best engineering practices (DOE, CPM, CTQ, FMEA etc.)
  • Proven experience with complex projects using external design resources and contract manufacturers
  • Familiarity with scientific instrument control, laboratory automation and liquid handling

Bonus Qualifications


  • Experience working with complex scientific applications
  • Experience with active microfluidics and control systems
  • Familiarity with Design Controls process and environment (ISO, cGMP etc.)
  • Ability to generating wiring diagrams as well as P&ID (SolidWorks Electrical)
  • Python programming skills
  • Motion and Industrial controls experience 
  • Quick turn / rapid prototyping experience
  • Previous experience in Biotech
  • ECAD experience - Altium Design, KiCAD
  • CAM experience - HSMWorks
  • CNC experience - Haas & Datron


Company Perks & Benefits


  • Competitive salary
  • Generous equity at an early stage company
  • Robust medical, dental and vision benefits
  • 401k Plan
  • Fully stocked kitchen and snacks
  • Free catered lunches and dinners
  • Onsite Machine Shop





Synthego is turning molecular biology into an information science. We're building hardware facilities that abstract biological syntheses and research into software.

Our vision is to bring automation to genome engineering, enabling scientists to run their own fully-automated laboratory at low cost, performing millions of controlled, repeatable experiments per day without human error.

Founded by former SpaceX engineers, Synthego is a leading provider of genome engineering solutions.  The company’s flagship product, CRISPRevolution, is a portfolio of synthetic RNA designed for CRISPR genome editing and research.

We are venture backed by Founders Fund, Menlo Ventures, 8VC, and WI Harper. 


Rev 20170925

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